Newly discovered mechanism regulates cholesterol metabolism

first_imgGökhan Hotamisligil is on a mission to help us survive our affluence and its attendant cardiometabolic diseases. His prolific laboratory at the Harvard T.H. Chan School of Public Health and Sabri Ülker Center for Nutrient, Genetic, and Metabolic Research has recently generated another line of inquiry that could lead to treatments or prevention strategies for heart disease, stroke, and other disorders.Led by postdoctoral fellow Scott Widenmaier, the team has found a “molecular guardian,” as Hotamisligil has dubbed it, which senses the toxic buildup of cholesterol within cells and triggers powerful protective responses.The research, published last November in Cell, represents a natural outgrowth of studies that Hotamisligil has conducted for more than 25 years on metabolism, nutrition, obesity, and the immune system. A decade ago, this line of inquiry led him to the endoplasmic reticulum, a distribution center within cells where proteins are processed, stored, and packaged for delivery to their ultimate cellular destinations.“We made a series of discoveries which told us that the endoplasmic reticulum may have a much bigger function in the cell, especially on metabolic health, and operate almost like an environmental surveillance device,” says Hotamisligil, who is chair of the Department of Genetics and Complex Diseases, the J.S. Simmons Professor of Genetics and Metabolism, and director of the Sabri Ülker Center.Cholesterol’s vital rolesHotamisligil’s discoveries have shed light on the molecular basis of obesity, diabetes, and other cardiometabolic disorders, as well as age-associated pathologies such as neurodegeneration. As he and his colleagues uncovered the role of the endoplasmic reticulum in protecting cells from shortages or surpluses of certain molecules, the researchers turned their attention to cholesterol. “One thing which dawned on us was a huge gap in the understanding of cholesterol homeostasis,” says Hotamisligil.For all the bad press it gets, cholesterol is one of the most important molecules in the body, comprising 25 to 30 percent of our cell membranes and helping give them the perfect balance of stability and flexibility that animal cells need. But since evolution is a resourceful tinkerer, plentiful molecular actors like cholesterol have been drafted for many roles: hormone and vitamin production, digestion, signaling, and others. While most cells in the body can generate some cholesterol, the main source is the liver, and to a smaller extent, cholesterol-containing foods. With so much riding on cholesterol, the body has mechanisms to ensure that there is enough, including a sensor in the membrane of the endoplasmic reticulum called SREBP2, a protein that signals any need to boost cholesterol synthesis. Read Full Storylast_img read more

OFFICIAL:Harambee Stars qualify for AFCFON

first_img“The CAF Executive Committee at its meeting on Friday, 30 November 2018 in Accra decided on the case of Sierra Leone in the 2019 Total Africa Cup of Nations qualifiers. Sierra Leone is disqualified from the qualifiers and all its matches are annulled,” CAF said in its statement on Monday.With one round of qualification matches left, the decision leave Kenya top of Group F with seven points, one ahead of second placed Ghana and six ahead of Ethiopia.Stars and Ghana are both through and their meeting in march next year will be merely to see who tops the group.0Shares0000(Visited 2 times, 1 visits today) 0Shares0000Harambee Stars players celebrate Eric Johannah’s goal against Ethiopia in a 2019 African Cup of Nations qualifier at the Moi Sports Centre Kasarani on October 14, 2018. PHOTO/Raymond MakhayaNAIROBI, Kenya, Dec 3 – National football team Harambee Stars have qualified for the 2019 African Cup of Nations (AFCON) after the Confederation of African Football (CAF) made it official on Monday that Sierra Leone have been disqualified from the qualifiers.An Extraordinary Executive Committee meeting in Accra, Ghana on Friday made the decision with Sierra Leone yet to drag itself off their ban by FIFA over government interference.last_img read more


first_imgFORGET the Yellow Jersey – or even the Pink Jersey!The only place to be this Saturday when it comes to cycling is in Le Tour De Diamond – Donegal Town’s annual charity 24-hour cycle.And as you may have guessed, it doesn’t actually leave the centre of the town! It’s all part of fundraising by the Parents Association for Scoil Aodh Rua agus Nuala in Donegal Town.Le Tour starts at 4pm on Friday and finishes at 4pm on Saturday. The aim of the cycle is to raise funds for new computers, literacy, numeracy & PE Equipment.This is the 2nd year of the 24 hour cycle and last year parents raised more than €4,000!click here for more Many Thanks NiamhDONEGAL TOWN GETS READY FOR 24-HOUR TOUR DE DIAMOND was last modified: June 12th, 2014 by John2Share this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Donegal TownfundraiserSCHOOLScoil Aodh Rua agus NualaTour de Diamondlast_img read more

SA paddlers win Liffey Descent

first_imgWorld Student GamesThe Louw brothers now fly to Hungary for a training camp with coach Atilla Adrovicvz before heading for the World Student Games in Bosnia. After that they will return to South Africa for the Hansa Powerade Fish Canoe Marathon on the first weekend in October. “It was probably the greatest race of my life!” enthused Ryan Louw afterwards. The Hansa Powerade Fish River Canoe Marathon gets under way at Grassridge Dam and finishes in Cradock. More information can be found at Hansa Powerade Fish River Canoe Marathon. With Ryan having bagged a third at the national K1 river champs in the Tracker Highland Challenge, they are well poised to fly the flag high for the Eastern Cape at the famous race in Cradock on 3 and 4 October. 19 September 2008 They were, however, able to make contact with Irish marathon ace Gary Mawer, who was able to start an eleventh-hour search for spare kayaks for the stranded South Africans. ‘Fixing the boat’“Gary loaned us an old K2 that had won five Liffeys, the first being around 1990,” said Greg Louw. The Louw brothers managed to get their borrowed K2 repaired in time and were locked in a ferocious tussle for the overall lead with locals Malcolm Banks and Dermot Hudson, and another South African pair, Brett Irvine and Julian Callebaut, who were paddling for the London-based Richmond Canoe Club. Fish entriesLate entries are still being taken for the race, which has once again attracted a substantial field of paddlers from all corners of the country to Cradock. The event will also double as the Eastern Province K2 River Championships. The man who saved the South Africans’ races by arranging replacement kayaks, Gary Mawer, won the singles race. Maiden winIn the latter stages of the race the Louw brothers were able to make their move to win their maiden Liffey title by two minutes. center_img Lost amid all the recent good news stories in South African sport was another big success for the Rainbow Nation in the Liffey Descent Canoe Marathon in Ireland last weekend. Brothers Ryan and Greg Louw, paddling in a borrowed kayak, claimed victory to continue a strong South African tradition of excellence in the race. South African crews filled the majority of the top five K2 places, with Scott Humphrey and Christopher Couve finishing fifth. KZN students Dylan Scott and Mark Ussher were tenth and the mixed doubles crew of Kelly Howe and Craig Turton finished fifteenth overall. They are both students at the Nelson Mandela Metropolitan University in Port Elizabeth and have been the top Eastern Cape crew for a number of years. They finished seventh in the last K2 Fish in 2006. “It was set up with a t-bar steering system, and needed quite a bit of repair work. So we spent the day before the race fixing the boat instead of tripping the river! LIFFEY DESCENT RESULTS “Luckily we had taken our own seats with us as hand-luggage on the plane, so we were able to fit those to the boat for the race,” he added. The brothers, together with a number of other South Africans, arrived at the harbour in Dublin to collect their kayaks that they had freighted to Ireland especially for the race, only to discover that the container was in Singapore. K2 RACE1. Greg Louw/Ryan Louw 1:48:59 (RSA)2. Malcolm Banks/Dermot Hudson1:50:113. Brett Irvine/Julian Callebaut 1:50:12 (RSA)4. Kevin Pierce/Vincent Pierce1:53:065. Scott Humphrey/Christopher Couve1:54:42 (RSA)6. Trenton Lamble/Chris Muller 1:54:43 (RSA)7. Aisa Cooper/Dave Pringle1:56:408. Eoin Rheinisch/Barry Watkins1:58:339. Ciarane Cooke/Don O’Brien1:58:3410. Liam McCarthy/Sean McCarthy1:59:5011. Dylan Scott/Mark Ussher 2:03:06 (RSA)15. Kelly Howe/Craig Turton2:09:05 (RSA) Source: Canoeing South Africalast_img read more

Joining hands with Sena will be fatal for Congress: Nirupam

first_imgFormer Mumbai Congress president Sanjay Nirupam on Thursday said it would be a mistake if his party joins the Shiv Sena-led government being planned in Maharashtra. The former MP said the move would mean the beginning of the Congress’s burial in Maharashtra.The former MP appealed to Congress chief Sonia Gandhi against coming under pressure in this regard. To prove his point, Mr. Nirupam said the Congress had committed the mistake of joining hands with the Bahujan Samaj Party (BSP) in Uttar Pradesh a few years ago, and ended up losing ground in such a manner that it has still not recovered.The leaders of the Congress and the Nationalist Congress Party (NCP) held a series of meetings in Delhi to finalise the decision to team up with the Sena to form a government in Maharashtra. While the meeting with the Sena is planned on Friday, sources indicate that leaders of both parties have agreed to finalise government formation with the Sena.‘Repeating mistake’“The Congress had committed a mistake by joining hands with the BSP in Uttar Pradesh years ago. It failed so badly then that it still has not recovered. We are committing the same mistake in Maharashtra,” said Mr. Nirupam, who was with the Sena before he joined the Congress.“For the Congress to become the No. 3 party in the Shiv Sena government is like burying it here. It will be better if the Congress president doesn’t come under pressure,” he said.The Sena, NCP and Congress won 56, 54 and 44 seats respectively in the October 21 Assembly polls. The Bharatiya Janata Party, which emerged as the single largest party with 105 seats, is falling short of 40 MLAs to attain the majority mark.last_img read more

A joint effort to conserve water in Rajasthan

first_imgVillagers and elected representatives of Panchayati Raj bodies in Rajasthan will assist the State government in its efforts for water conservation and rainwater harvesting, which are expected to increase the groundwater level in the geographically difficult areas. The projects have been formulated to meet the local needs with regular monitoring.The Rajiv Gandhi Jal Sanchay Yojana (RGJSY), launched in all the 33 districts of the State on August 20 this year, has identified as many as 1.80 lakh works to be executed in its first phase for creating a robust water harvesting infrastructure in over 3,900 villages.Erratic rainfallChief Secretary D.B. Gupta said here on Wednesday that the RGJSY’s long-term projects would permanently resolve the issue of paucity of water caused by scanty and erratic rainfall in the State. The completion of works through convergence with the departments concerned will ensure the availability of sufficient water for drinking and irrigation.The RGJSY has incorporated the works identified in the Mukhya Mantri Jal Swavalamban Abhiyan undertaken during the previous BJP regime in the State. Proposals for making budgetary provisions under the State Plan for 2019-20 have been submitted to the Finance Department, while a meeting of the Water Cess Committee for making the water cess provision was convened on October 31.Mr. Gupta said at a meeting of the State-level committee on RGJSY that the contribution of villagers and elected representatives would help in identification of places where no water harvesting structures were constructed in the past. He laid emphasis on stopping the practice of flood irrigation.last_img read more

TCI Ministry of Health defends its public handling of Zika virus

first_img Related Items:Ministry of health defends its handling of Zika virus, potential law to allow ticketing for individuals breaking DEH health codes, public thinks government is too closed mouth about zika, residents need to do more to prevent breeding sites Many believe the same is happening with Zika which has spawned resort cancellations to the tune of hundreds of thousands of dollars.Origin of the Zika cases we asked?  No, we cannot know but three countries were confirmed as the source places.Why so slow for us to know we asked?  Confirmation on the five cases as Zika was needed, media was told.  Yet all five cases are separate instances and we only knew at five.  Now there are reportedly eight; this approach to not sharing from the very first case has many believing that the TCI is beyond the eight revealed cases which includes a pregnant woman. What about the $550,000 in Solid Waste Management money we asked?  We were told it is for the Premier to say.  The Premier, who is also the Minister of Health was not there at the press conference to say.  And when Magnetic Media asked why?  Well there was no true reply, except that one day, some day, the Health Minister will share the solid waste management plan.New to your fight?  Door to door inspections and visits supported by the TCI Red Cross, we were told.Also new… ticketing for breaches in the environmental health codes for residential, industrial and commercial properties. The law, however, to get that enforcement started is likely three months from implementation.At times it was a rowdy exchange between media and the two health directors in the hunt for clarity, transparency and accountability… including a cocksure posture by Health Officials about public perception on what is or is not being done.We informed that most believe nothing is happening to stop Zika Virus spreading in these islands.Biggest problem?  The public which refuses, in some cases, to acquiesce to the law and best practices to decrease breeding of that aedes Eqypti mosquito.Another, but not mentioned today by the Medical & Environmental Health Directors is the incessant rain.  A leaf is a great birthplace for a mosquito and so is a plant pot.The TCI is not alone and other countries do have Zika; but the TCI is unique and is one of the countries which has opted to omit the facts.  Often conveyed to Magnetic Media by Joe Public is concern over the secrecy and guardedness of info when this global health crisis which has now hit home within the past four weeks is a fight for the health and for the wealth of the nation by all.In the meantime, please do your part to become and advocate and participant in keeping the TCI free of more mosquito breeding sites. Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, TCI, August 16, 2016 – The Turks and  Caicos Ministry of Health defends its public handling of the Zika Virus; despite media conveying that residents are critical of their Public Relations. In a media conference today to share the national action plan, missing was the Minister of Health, Dr Rufus Ewing and present were Dr. Nadia Astwood and Mr Kenrick Neely who repeated commonly communicated information and gave little insight into the cases detected and confirmed; and scant information on what is new.Though the campaign against mosquito breeding at various times can be labeled vigorous, it has failed to resonate in a way to drive down the dangers as mosquito breeding sites continue to exist and actually flourish in too many communities.  The inability to get some residents to fall in line has actually led to the mushrooming of two mosquito borne diseases in the TCI; Dengue Fever since 2011 and Chikungunya Virus in 2014.center_img Facebook Twitter Google+LinkedInPinterestWhatsApplast_img read more