Gökhan Hotamisligil is on a mission to help us survive our affluence and its attendant cardiometabolic diseases. His prolific laboratory at the Harvard T.H. Chan School of Public Health and Sabri Ülker Center for Nutrient, Genetic, and Metabolic Research has recently generated another line of inquiry that could lead to treatments or prevention strategies for heart disease, stroke, and other disorders.Led by postdoctoral fellow Scott Widenmaier, the team has found a “molecular guardian,” as Hotamisligil has dubbed it, which senses the toxic buildup of cholesterol within cells and triggers powerful protective responses.The research, published last November in Cell, represents a natural outgrowth of studies that Hotamisligil has conducted for more than 25 years on metabolism, nutrition, obesity, and the immune system. A decade ago, this line of inquiry led him to the endoplasmic reticulum, a distribution center within cells where proteins are processed, stored, and packaged for delivery to their ultimate cellular destinations.“We made a series of discoveries which told us that the endoplasmic reticulum may have a much bigger function in the cell, especially on metabolic health, and operate almost like an environmental surveillance device,” says Hotamisligil, who is chair of the Department of Genetics and Complex Diseases, the J.S. Simmons Professor of Genetics and Metabolism, and director of the Sabri Ülker Center.Cholesterol’s vital rolesHotamisligil’s discoveries have shed light on the molecular basis of obesity, diabetes, and other cardiometabolic disorders, as well as age-associated pathologies such as neurodegeneration. As he and his colleagues uncovered the role of the endoplasmic reticulum in protecting cells from shortages or surpluses of certain molecules, the researchers turned their attention to cholesterol. “One thing which dawned on us was a huge gap in the understanding of cholesterol homeostasis,” says Hotamisligil.For all the bad press it gets, cholesterol is one of the most important molecules in the body, comprising 25 to 30 percent of our cell membranes and helping give them the perfect balance of stability and flexibility that animal cells need. But since evolution is a resourceful tinkerer, plentiful molecular actors like cholesterol have been drafted for many roles: hormone and vitamin production, digestion, signaling, and others. While most cells in the body can generate some cholesterol, the main source is the liver, and to a smaller extent, cholesterol-containing foods. With so much riding on cholesterol, the body has mechanisms to ensure that there is enough, including a sensor in the membrane of the endoplasmic reticulum called SREBP2, a protein that signals any need to boost cholesterol synthesis. Read Full Story
The Vermont Chapter will receive a Continuing Publication Commendation from the Construction Specifications Institute (CSI) for its monthly newsletter, Green Mountain Specifier. Christopher Eling, CSI, CDT, editor of the newsletter, will accept the award April 21, 2004 during the Opening General Session of The 48th Annual CSI Showä & Convention.CSI presents a Continuing Publication Commendation to individuals, chapters, firms, or organizations for outstanding publications in areas related to the Institute. The Vermont Chapter nominated Eling and the Green Mountain Specifier for:- Consistently providing the construction community with news from the chapter, region, and Institute- Publishing technical and educational articles by members and industry experts- Reviewing past, present and future chapter programs- Recognizing new members- Promoting and recognizing certification and member accomplishmentsThe Green Mountain Specifier is published 10 times each year.Eling has been a member of CSI for three years, and works for Peter Morris Architect in Vergennes, VT.The Opening General Session will take place on Wednesday, April 21, in Chicago, and will be open to the public. For more information about the Show & Convention, visit www.thecsishow.com(link is external).The Vermont Chapter of the Construction Specifications Institute will receive both of this year’s Chapter Cup awards during the Institute’s Annual Meeting on Saturday, April 24th in Chicago. CSI awards two Chapter Cups each year to recognize the chapters that grew the most during the previous calendar year. Because one cup is awarded based on percentage growth in membership, and the other based on net growth, it is unprecedented that a single chapter wins both cups in one year.The Vermont Chapter grew from 57 to 126 members last year, a 122 percent increase. The Vermont Chapter was chartered in May 1968 with 30 members. The chapter has been active and growing in recent years, and was able to take home Chapter Cup awards for highest percentage growth in 2000 and 2001.Vermont leaders credit their success to a strong continuing education program for construction practitioners and efforts to reach students in construction-related programs at Norwich University and Vermont Technical College.About CSICSI is a national association of specifiers, architects, engineers, contractors, building materials suppliers and others involved in nonresidential building design and construction.
Jul 17 2009 (CIDRAP News) – Novel flu activity is still going strong but dropped for the third week in a row, the US Centers for Disease Control and Prevention (CDC) said today during a media briefing that also sought to calm fears about vaccine availability.Anne Schuchat, MD, director of the CDC’s National Center for Immunization and Respiratory Diseases, said the CDC will probably follow the World Health Organization’s (WHO’s) lead and phase out weekly reports of lab-confirmed cases, which grossly underestimate the true disease burden and divert resources from other pandemic response activities. She said over the next several weeks the agency will start adding new data and other enhancements to its weekly flu report to provide a more detailed profile of the nation’s activity.The CDC’s update today, however, reports that the country’s number of lab-confirmed cases has reached 40,617, of which 263 were fatal.In its flu surveillance report for the week ending Jun 11, the CDC said nine states reported widespread activity: California, Delaware, Georgia, Hawaii, Maine, Maryland, Nebraska, New Jersey, and New York. Twelve states and Puerto Rico reported regional influenza activity.More than 99% of flu isolates that have been subtyped are the novel H1N1 virus, the CDC reported. One of three cases of oseltamivir-resistant viruses detected worldwide was from a child who got sick in California and traveled to Hong Kong. Enhanced antiviral-resistance testing in California has not revealed any oseltamivir-resistant novel H1N1 viruses, the CDC said.One pediatric death from the new virus was reported during the past week, in a child from Massachusetts. Of the 90 fatal pediatric flu cases that have been reported to the CDC so far this season, 23 were novel H1N1 infections.Schuchat said the virus might be persisting through the summer, despite the heat and humidity, because of the US population’s low immunity to the novel virus rather than because the virus has mechanisms for coping with the conditions. However, she said the CDC doesn’t have the data to flesh out its theory about the summer spread.The CDC expects flu activity to start rising again in September, ahead of the regular flu season, which would coincide with kids congregating in greater numbers as school resumes, she said. The CDC and its partners are in the active stage of planning for a spike in pandemic H1N1 flu activity in early fall, she added.The CDC’s Advisory Committee on Immunization Practices (ACIP) will hold an emergency meeting on Jul 29 to discuss recommendations for which populations should be targeted for novel H1N1 flu vaccination and whether tiering the vaccine prioritization would be appropriate, Schuchat told reporters.Two federal officials who are involved in high-level vaccine decisions were on hand at the press conference to address recent questions that have cropped up about disappointingly low novel flu vaccine yield and potential international squabbles over vaccine supplies. The officials were Jesse Goodman, MD, the Food and Drug Administration’s acting chief scientist and deputy commissioner for scientific and medical programs, and Bruce Gellin, MD, director of the National Vaccine Program, Department of Health and Human Services.Gellin said federal officials have stockpiled antigen and adjuvant and that National Institutes of Health investigators, as well as researchers at vaccine companies, are starting to test both adjuvanted and nonadjuvanted versions of the novel flu vaccine. Stockpiling the bulk ingredients gives US officials greater flexibility in pulling together a safe and effective vaccine for its citizens, he said.Schuchat said the CDC has heard concerns about vaccine manufacturers in foreign countries diverting vaccine orders to their own populations. “From our own planning, this is not one of our current concerns,” she said. “We haven’t received any information that makes us question the supply of what’s been promised.”As for poor antigen yields that some manufacturers are reporting for the new virus, Schuchat said the CDC is not surprised and has already incorporated such yields into its planning and vaccine production expectations. “It’s within the range of our planning assumptions, but of course there could always be some surprises,” she said.
Lionel Messi set another LaLiga record on Saturday as Barcelona made a winning return in LaLiga.Madrid, Spain | AFP | Lionel Messi returned without a beard and with a goal and two assists as Barcelona resumed their La Liga title challenge on Saturday with a thumping 4-0 victory over Real Mallorca.After three months away because of the coronavirus pandemic, Barca exploded into the lead with just 64 seconds played when Arturo Vidal headed in and Martin Braithwaite struck a second from a Messi headed assist.Jordi Alba latched onto a Messi pass to add a third but not before play was briefly stopped by a pitch invader, who was able to run on, despite the match being closed to fans.Messi then scored a fourth in injury time for his 25th goal of the season.“I’m happy because starting like this is an enormous boost for what’s to come,” said Barcelona coach Quique Setien.Victory extends Barca’s advantage at the top of La Liga to five points over Real Madrid, who can reduce the gap back to two when they restart at home to Eibar on Sunday.La Liga’s first match back came on Thursday between Sevilla and Real Betis, with teams scheduled to each play their remaining 11 matches of the season in less than six weeks.Messi will be crucial to Barcelona’s hopes of holding off Madrid but their captain, who turns 33 this month, may have to pace himself, especially after an injury-interrupted season.Clean shaven, and without any sign of the thigh problem that prevented him from training earlier this month, Messi played 90 minutes and looked like he had never been away.– Suarez back –His goal was set up by Luis Suarez and the sight of the Uruguayan coming off the bench would have been welcome for coach Setien too.Suarez has not played since undergoing knee surgery in January and was able to recover during the suspension. He could play an important part in the run-in.Asked what pleased him most, Setien said: “The satisfaction of seeing Luis again on the field. You have to admire the performance he gave in those 35 minutes that he played. Starting like this is very important for him and for the team as well.” Mallorca, who sit 18th in La Liga, were never going to offer the sternest of tests but this was a useful outing for both Barcelona’s fitness and morale.Before matches were suspended in Spain because of coronavirus on March 12, Barca had regained top spot but only after being convincingly beaten by Madrid the week before.This performance suggests time away might have done them good and it remains to be seen now how Madrid respond. Madrid’s next four matches all come after their title rivals have played first.Barcelona were in front after just over a minute as Frenkie de Jong did well to recover the ball from a loose touch before Alba sent a deep cross to the arriving Vidal, who headed in.Mallorca were under relentless pressure as Braithwaite and Messi both went close to adding a second. Mallorca’s Takefusa Kubo, on loan from Real Madrid, forced a good save out of Marc-Andre ter Stegen on the break.But Barca scored a second before half-time as an Alba cross span up and both De Jong and then Messi feathered headers across for Braithwaite to bang in on the half-volley, his first goal for the club.Both teams eased off in the second period and there were smiles on the Barcelona players’ faces when a pitch invader ran on in the 52nd minute wearing an Argentina shirt. He posed for a picture with Alba before being escorted away.Alba added a third after finishing off Messi’s clipped ball over the top and then Messi grabbed a goal himself. Suarez fooled his marker by letting the ball run across his body and Messi weaved inside where he could unleash with his right foot.Mallorca’s defeat, combined with losses for Leganes and Celta Vigo, made it the perfect day for Espanyol, who made up ground on their relegation rivals by beating Alaves.Chinese striker Wu Lei, who tested positive for coronavirus in March, scored on his first game back to seal a 2-0 victory and put Espanyol within three points of safety.They are now level on points with Leganes, who lost 2-1 at home to Real Valladolid, and three behind Celta, who conceded in the 91st minute for a 1-0 defeat by Villarreal. Share on: WhatsApp